Our Clinicians

Shona T. Dougherty, MB, ChD, PhD

Associate Professor, Department of Radiation Oncology

EDUCATION

Medical School: University of Edinburgh, Edinburgh, Scotland
Residency: Radiation Oncology, University of British Columbia, Vancouver, Canada

PROFESSIONAL EXPERIENCE

University of California Los Angeles, Los Angeles, CA
Assistant Professor, Radiation Oncology 1996-2003
Associate Professor, Radiation Oncology 2003

The University of Arizona, Tucson, AZ
Associate Professor, Radiation Oncology 2003-present

SELECTED PUBLICATIONS

Dougherty ST, Eaves CJ, McBride WH, Dougherty GJ. Molecular mechanisms regulating TNF- a production by tumor-associated macrophages. Cancer Lett. 1997;111:27-37.

Dougherty ST, Eaves CJ, McBride WH, Dougherty GJ. Role of macrophage-colony-stimulating factor in regulating the accumulation and phenotype of tumor-associated macrophages. Cancer Immunol Immunother. 1997;44(3):165-172.

Safa AA, Reece DM, Carter DM, Phillipson J, Smith R, Dougherty ST. Undetectable serum prostate-specific antigen associated with metastatic prostate cancer: a case report and review of the literature. Am J Clin Oncol. 1998;21(4): 323-326.

Renschler MF, Yuen AR, Panella TJ, Wieman TJ, Dougherty S, Esserman L, Panjehpour M, Taber SW, Fingar VH, Lowe E, Engel JS, Lum B, Woodburn KW, Cheong W-F, Miller RA. Photodynamic therapy trials with Lutetium Texaphyrin (Lu-Tex) in patients with locally recurrent breast cancer. Proceedings of Optical Methods for Tumor Treatment and Detections: Mechanisms and Techniques in Photodynamic Therapy VII. 1998;3247:35-39.

Chiu RK, Droll A, Dougherty ST, Carpenito C, Cooper DL, Dougherty GJ. Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44. Exp Cell Res. 1999;248(1):314-321.

Chiu RK, Carpenito C, Dougherty ST, Hayes GM, Dougherty GJ. Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. Neoplasia. 1999;1(5):446-452.

Hayes GM, Carpenito C, Davis PD, Dougherty ST, Dirks JF, Dougherty GJ. Alternative splicing as a novel means of regulating the expression of therapeutic genes. Cancer Gene Ther. 2002;9(2):133-141.

Carpenito C, Davis P, Dougherty ST, Dougherty GJ. Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapy-based approach to the treatment of cancer. Int J Radiat Oncol Biol Phys. 2002;54:1473-1478.

Hayes G, Chiu RK, Carpenito C, Dougherty ST, Dougherty GJ. Identification of sequence motifs responsible for the adhesive interaction between exon v10-containing CD44 isoforms. J Biol Chem. 2002;277(52):50529-50534.

Hayes GM, Dougherty ST, Davis PD, Dougherty GJ. Molecular mechanisms regulating the tumor targeting potential of splice-activated gene expression. Cancer Gene Ther. 2004;11(12):797-807.

Dougherty ST , Davis PD, Dougherty GJ. Vascular-targeted cancer gene therapy. Expert Opin Biol Ther. 2004;4(12):1911-1920.

Division of Women's Cancers
Arizona Cancer Center
1515 N. Campbell Ave.
PO Box 245024
Tucson, AZ 85724-5024
Phone: 520-626-0950
Fax: 520-626-8574
E-mail: sskszek@azcc.arizona.edu

	Our Clinicians Shona T. Dougherty, MB, ChD, PhD Associate Professor, Department of Radiation Oncology EDUCATION Medical School: University of Edinburgh, Edinburgh, Scotland Residency: Radiation Oncology, University of British Columbia, Vancouver, Canada PROFESSIONAL EXPERIENCE University of California Los Angeles, Los Angeles, CA Assistant Professor, Radiation Oncology 1996-2003 Associate Professor, Radiation Oncology 2003 The University of Arizona, Tucson, AZ Associate Professor, Radiation Oncology 2003-present SELECTED PUBLICATIONS Dougherty ST, Eaves CJ, McBride WH, Dougherty GJ. Molecular mechanisms regulating TNF- a production by tumor-associated macrophages. Cancer Lett. 1997;111:27-37. Dougherty ST, Eaves CJ, McBride WH, Dougherty GJ. Role of macrophage-colony-stimulating factor in regulating the accumulation and phenotype of tumor-associated macrophages. Cancer Immunol Immunother. 1997;44(3):165-172. Safa AA, Reece DM, Carter DM, Phillipson J, Smith R, Dougherty ST. Undetectable serum prostate-specific antigen associated with metastatic prostate cancer: a case report and review of the literature. Am J Clin Oncol. 1998;21(4): 323-326. Renschler MF, Yuen AR, Panella TJ, Wieman TJ, Dougherty S, Esserman L, Panjehpour M, Taber SW, Fingar VH, Lowe E, Engel JS, Lum B, Woodburn KW, Cheong W-F, Miller RA. Photodynamic therapy trials with Lutetium Texaphyrin (Lu-Tex) in patients with locally recurrent breast cancer. Proceedings of Optical Methods for Tumor Treatment and Detections: Mechanisms and Techniques in Photodynamic Therapy VII. 1998;3247:35-39. Chiu RK, Droll A, Dougherty ST, Carpenito C, Cooper DL, Dougherty GJ. Alternatively spliced CD44 isoforms containing exon v10 promote cellular adhesion through the recognition of chondroitin sulfate-modified CD44. Exp Cell Res. 1999;248(1):314-321. Chiu RK, Carpenito C, Dougherty ST, Hayes GM, Dougherty GJ. Identification and characterization of CD44RC, a novel alternatively spliced soluble CD44 isoform that can potentiate the hyaluronan binding activity of cell surface CD44. Neoplasia. 1999;1(5):446-452. Hayes GM, Carpenito C, Davis PD, Dougherty ST, Dirks JF, Dougherty GJ. Alternative splicing as a novel means of regulating the expression of therapeutic genes. Cancer Gene Ther. 2002;9(2):133-141. Carpenito C, Davis P, Dougherty ST, Dougherty GJ. Exploiting the differential production of angiogenic factors within the tumor microenvironment in the design of a novel vascular-targeted gene therapy-based approach to the treatment of cancer. Int J Radiat Oncol Biol Phys. 2002;54:1473-1478. Hayes G, Chiu RK, Carpenito C, Dougherty ST, Dougherty GJ. Identification of sequence motifs responsible for the adhesive interaction between exon v10-containing CD44 isoforms. J Biol Chem. 2002;277(52):50529-50534. Hayes GM, Dougherty ST, Davis PD, Dougherty GJ. Molecular mechanisms regulating the tumor targeting potential of splice-activated gene expression. Cancer Gene Ther. 2004;11(12):797-807. Dougherty ST , Davis PD, Dougherty GJ. Vascular-targeted cancer gene therapy. Expert Opin Biol Ther. 2004;4(12):1911-1920.
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Division of Women's Cancers Arizona Cancer Center 1515 N. Campbell Ave. PO Box 245024 Tucson, AZ 85724-5024 Phone: 520-626-0950 Fax: 520-626-8574 E-mail: sskszek@azcc.arizona.edu
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